San Myotest 90 Caps

Myotest is the first and only true "Triple-Threat" that simultaneously enhances and liberates test while manipulating estrogen. That's precisely what you need if you're interested in getting huge, strong and ripped. Myotest has not only taken the purity of 3,4-Divanilly to another level (over 97%), it's the only product that also supplies the secret "weapons of mass construction" (Icariin, Osthole, Quercetin and Resveratrol) in a perfect ratio. This means that when you use it, you'll see and feel what the world?s most advanced scientifically engineered supplement is capable of in terms of increasing ripped muscle mass, enhancing bed performance and super strength gains in the gym. LH-Boosting, Pro-Sexual & CYP-450

Mediated Support Matrix:

(Quercetin-96%, Epimedium Standardized For 30% Icariins, Cnidium Monnieri Standardized For 40% Osthole). Aromatase Eradicator &

Testosterone Trigger:

(Resveratrol-45%, Indole-3-Carbinol, Bioperine, Zinc Monomethionine). SHBG Blocking &

Free Test Amplifier:

(3,4-Divanillyltetrahydrofuran 97% [Urtica Dioica]).

Directions

As a dietary supplement, take 3 capsules twice daily, each time with food.

PLEASE NOTE: Product image is representative of the product offered but may not have the exact attributes. Please read product description for the specific attributes of this product.

MYOTEST FORMULA RATIONALE The object of this astonishing invention is to provide an effective non-hormonal supplement that aids to the strength and stamina of its user. The preferred embodiments comprise of: 3, 4-Divanillyltetrahydrofuran, Icariin, Indole-3-Carbinol, Cnidium Monnier, Resveratrol, Quercetin & Piperine. A short synopsis of each ingredient and the rationale for its inclusion are hereby included forthwith:

3, 4- Divanillyltetrahydrofuran (Stinging Nettle Root) Science tells us that only 2% of the bodies total testosterone supply is actually free and unbound (active). In order to fully reap the benefits of testosterone we need to harness as much unbound testosterone from binding proteins as humanly possible. The two proteins we are talking about are known as albumin and serum hormone binding globulin, or SHBG for short. Meet 3, 4-Divanyl. By employing an exclusive extraction technology, SAN is able to harness a large percentage of this lignan (ordinarily, only 1% is contained). One exciting part of 3, 4-Divanyl is that it has been scientifically demonstrated to bind to SHBG, and, in turn, occupies the parking space which otherwise bounds itself to testosterone rendering it useless. The end result is increased levels of test which manifests itself by dramatically enhancing strength and mood; and, thereby radically altering body composition. Another favorable mechanism of 3, 4-Divanyl which was recently discovered is nothing short of amazing. By stimulating a second messenger in nitric oxide synthase, 3, 4-Divanyl triggers vital pathways involved in muscle cell proliferation by positively affecting insulin sensitivity and, thus, enhancing the famous muscular pump & Nutrient Delivery during exercise.

Icariin (Epimedium) Icariin, a flavonol glycoside, is a very interesting substance, which is commonly found in a plant known as Epimediumaka Horny Goat Weed. Used for centuries in Chinese herbal medicine, Icariin is often prescribed as a natural resource in treating (ED) erectile dysfunction. Its chief mechanism has been demonstrated to act on phosphodiesterase type 5 (PDE5) and to enhance the production of nitric oxide as well as mimicking the effects of testosterone. It also shows great promise as an anti-oxidant as well as to stimulate osteoblasts which can positively affect bone tissue. Similar to 3, 4-Divanyl, Icariin prolongs the muscular pump during exercise therefore increasing blood flow to muscle and penile tissue which are otherwise inhibited by PDE5, the gate keeper of cGMP (guanosine monophosphate).

Indole-3-Carbinol (I3C) I3C is produced by the breakdown of the glucosinolate glycobrassin which can be found in high concentrations of cruciferous vegetables such as broccoli and cauliflower. I3C is the subject of ongoing biomedical research into its possible antioxidant, anti-estrogen and anti-atherogenic effects. Its main mechanism that brought the ingredient to Myotest revolves around its ability to modulate positive (yes there are good and bad estrogens) estrogen metabolism. By hydroxylating the bad estrogen metabolites 16-alpha-hydroxyestrone & 4-hydroxyestrone into a benign pathway of (good) estrogen metabolites otherwise known as 2-hydroxyestrone, I3C keeps estrogen metabolism optimized and thus opens the flood gate to uninhibited testosterone formation. In addition, I3C also improves prostate function, enhances insulin sensitivity and may stimulate abdominal fat loss.

Cnidium Monnier (Osthole) Cnidium Monnier, also known in the Chinese medicine as She Chuang Zi, has a long history in the far-east as an herbal medicine that improves male sexual dysfunction. The constituent responsible for this effect is believed to be a coumarin compound found in Cnidium, called osthole. Osthole was found to help relax the corpus cavernosa of the penis by inhibiting the activity of cAMP and phosphodiesterases (PDE5) in a concentration-dependent manner, which can potentially help with blood flow in those with erectile dysfunction (similar to Icarrin thus providing the user an additive effect). Ostholes secondary mechanism revolves around its Nitric Oxide releasing effects by increasing the production of cGMP which is the chief gate keeper from obtaining and sustaining a powerful erection.

Quercetin & Resveratrol (Japanese Knotweed) Resveratrol is a phytoalexin produced naturally by several plants under attack of pathogens as a natural defense mechanism. As contained in Myotest, Resveratrol is produced through the extraction of Japanese Knotweed. Resveratrol is also found in the skin of red grapes and is a constituent of red wine, but apparently not in sufficient amounts to elicit a positive health promoting effect. Just like Resveratrol, Quercetin is found in red grapes, but unlike Resveratrol, Quercetin belongs to the class of polyphenolic compounds called flavonoids, which are plant pigments that give colors to flowers, fruits, vegetables, and herbs. Resveratrol is a powerful antioxidant, a factor to which its heart-protective effects are largely attributed. In laboratory studies, Resveratrol inhibits platelet aggregation (the process by which blood clots are formed) and lipid peroxidation, which is an important factor in the development of atherosclerosis. The lipids in question are those that are carried in the bloodstream by LDL (low-density lipoprotein, or bad cholesterol), and their degradation by oxidizing agents such as free radicals facilitates their incorporation into artery-clogging plaque. Another interesting mechanism that brought Resveratrol to Myotest revolves around its ability to act as estrogen receptor antagonist. As such, the substance binds reversibly to the estrogen receptors, which in turn blocks the interaction with circulating estrogen hormones. The end result is a dramatic surge in testosterone levels (in excess of 50%) to combat the attenuated estrogen signal created by Resveratrol. An easier way to look at this, imagine a thermostat that kicks in to start the header once the temperature falls below a certain threshold. This is what happens to Testosterone (surges) once the body senses the presence of Resveratrol. Resveratrol has one pitfall which concerns its bioavailability. Upon ingestion, Resveratrol is rapidly absorbed (at least 70%) by the gut, however, its bioavailability is only close to 3-5% owing its rapid conversion to two derivatives known as: sulfates and glucoronides. This is where Quercetin comes to the rescue. Three recent university studies point out- that combining Quercetin with Resveratrol inhibits sulfation & glucoronidation in the gut and liver; thus, improving Resveratrols bioavailability. However, large doses must be taken to elicit this effect as enzyme blocking is only partially effective. Fortunately, the amount contained in Myotest mimics the exact proportions in the aforementioned studies.

References Cited

Resveratrol
1. Gescher AJ, Steward WP. Relationship between mechanisms, bioavailability, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol Biomark Prev 2003;12:953-7.
2. Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 2004;32:1377-82.
3. Wenzel E, Somoza V. Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res 2005;49:472-81.
4. Wenzel E, Soldo T, Erbersdobler H, Somoza V. Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Mol Nutr Food Res 2005;49:482-94.
5. Yu CW, Shin YG, Chow A, Li YM, et al. Human, rat, and mouse metabolism of resveratrol. Pharm Res 2002;19:1907-14.
6. De Santi C, Pietrabissa A, Spisni R, Mosca F, Pacifici GM. Sulfation of resveratrol, a natural product present in wine, and its inhibition by natural flavonoids. Xenobiotica 2000;30:857-66.
7. De Santi C, Pietrabissa A, Mosca F, Pacifici GM. Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. Xenobiotica 2000;30:1047-54.
8. Pacifici GM. Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature. Int J Clin Pharmacol Therapeut 2004;42:488-95.
9. Shin S, Jeon JH, Park D, Jang MJ, trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo. Choi JH, Choi BH, Joo SS, Nahm SS, Kim JC, Kim YB.
College of Veterinary Medicine, Chungbuk National University, Heungdeok-gu, Cheongju, Chungbuk 361-763, Korea. Arch Pharm Res. 2008 Jan;31(1):83-7.Links

Quercetin
1. Hendler SS, Rorvik D, eds. PDR for Nutritional Supplements. Medical Economics Company, Montvale, NJ, 2001, pp 397-401.
2. Sun AY, Simonyi A, Sun GY. The French paradox and beyond: neuroprotective effects of polyphenols. Free Rad Biol Med 2002;32(4):314-8.
3. Jang MS, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997; 275:218-20.
4. Gescher AJ, Steward WP. Relationship between mechanisms, bioavailability, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol Biomark Prev 2003;12:953-7.
5. Kaldas MI, Walle UK, Walle T. Resveratrol transport and metabolism by human intestinal Caco-2 cells. J Pharm Pharmacol 2003;55:307-12.
6. Mochizuki M, Kajiya K, Terao J, Kaji K, Kumazawa S, Nakayama T, Shimoi K. Effect of quercetin conjugates on vascular permeability and expression of adhesion molecules. BioFactors 2004;22:201-4.
7. Dajas F, Rivera-Megret F, Blasina F, et al. Neuroprotection by flavonoids. Braz J Med Biol Res 2003;36:1613-20.

Indole-3-Carbinol
1. ^ Dashwood, RH, et al (2007). "Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.". Pharmacological research 55 (3): 224236. doi:10.1016/j.phrs.2007.01.009.Entrez PubMed 17317210
2. ^ Dashwood, RH, et al (1989). "Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response.". Carcinogenesis, Jan; 10 (1): 175181. doi:10.1093/carcin/10.1.175. PMID 2491968.Entrez PubMed 2491968
3. ^ Hsu, JC, et al (2006). "Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.". Biochem Pharmacol., Dec 15; 72 (12): 171423. doi:10.1016/j.bcp.2006.08.012.Entrez PubMed 16970927
4. ^ Culmsee, Carsten (1999). "Neuroprotection by Estrogens in a Mouse Model of Focal Cerebral Ischemia and in Cultured Neurons: Evidence for a Receptor-Independent Antioxidative Mechanism". Journal of Cerebral Blood Flow & Metabolism 19: 12631269. doi:10.1097/00004647-199911000-00011, http://www.nature.com/jcbfm/journal/v19/n11/full/9590625a.html.
5. ^ "Society for Neuroscience, "Estrogen's Influence on the Brain"".

Icarrin
1. ^ Liu JJ, Li SP, Wang YT. Optimization for quantitative determination of four flavonoids in Epimedium by capillary zone electrophoresis coupled with diode array detection using central composite design. Journal of Chromatography A. 2006 Jan 27;1103(2):344-9. PMID 16337210
2. ^ Makarova MN, Pozharitskaya ON, Shikov AN, Tesakova SV, Makarov VG, Tikhonov VP. Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats. Journal of Ethnopharmacology. 2007 Dec 3;114(3):412-6. PMID 17890032
3. ^ 53: Related Articles, LinksJiang Z, Hu B, Wang J, Tang Q, Tan Y, Xiang J, Liu J. Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum. Journal of the Huazhong University of Science and Technology. 2006;26(4):460-2. PMID 17120748
4. ^ Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006 Dec;68(6):1350-4. PMID 17169663 5. ^ Dell'agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E. Potent Inhibition of Human Phosphodiesterase-5 by Icariin Derivatives. Journal of Natural Products. 2008 Sep 9. PMID 18778098
6. ^ Xu HB, Huang ZQ. Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro. Vascular Pharmacology. 2007 Jul;47(1):18-24. PMID 17499557
7. ^ Zhang ZB, Yang QT. The testosterone mimetic properties of icariin. Asian Journal of Andrology. 2006 Sep;8(5):601-5. PMID 16751992
8. ^ Xie J, Sun W, Duan K, Zhang Y. Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities. Natural Product Research. 2007 Jun;21(7):600-5. PMID 17613817
9. ^ Zhao F, Tang YZ, Liu ZQ. Protective effect of icariin on DNA against radical-induced oxidative damage. Journal of Pharmacy and Pharmacology. 2007 Dec;59(12):1729-32. PMID 18053336
10. ^ Pan Y, Kong L, Xia X, Zhang W, Xia Z, Jiang F. Antidepressant-like effect of icariin and its possible mechanism in mice. Pharmacology, Biochemistry and Behaviour. 2005 Dec;82(4):686-94. PMID 16380159
11. ^ Pan Y, Zhang WY, Xia X, Kong LD. Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats. Biological and Pharmaceutical Bulletin. 2006 Dec;29(12):2399-403. PMID 17142971
12. ^ Pan Y, Kong LD, Li YC, Xia X, Kung HF, Jiang FX. Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats. Pharmacology, Biochemistry and Behaviour. 2007 May;87(1):130-40. PMID 17509675